Natural gas hydrate is a key future clean energy resource, and sand control is crucial in natural gas hydrate production. However, the sand control is still inefficient, which impedes industrialized development of natural gas hydrate. From production test carried out in the South China Sea, we found the separation of micrometer-sized sand from the fluid is the main challenge in sand control. Based on high-speed motion in our 3D rotating turbulent flow field of hydrocyclone, our study presents a new technology to realize efficient separation of micrometer-sized sand and breaking consolidation between hydrate and sand. As results of hydrocyclone separation experiments, we have the high separation efficiency that is up to 92.23% for silica sand and 98.87% for PP; also only 0.46%~1.05% of PP powder remains in recovered materials. In conclusion, the technology proves the ability of breaking-consolidation and realizes the goal of separation of micrometer-sized particles, and thus improve the sand control in exploitation of marine natural gas hydrate.